Improvement of glucose metabolism and safety of acacia bark-derived proanthocyanidins in healthy Japanese adults: A Randomized, Double-blind, Placebo-controlled, Parallel-group Trial

Objective: Acacia bark-derived proanthocyanidins exhibit antioxidant, anti-inflammatory, anti-diabetic, hypotensive effects, and improving skin condition, in addition to beneficial effects on blood glucose. Herein, we evaluated the of acacia fasting postprandial glucose levels healthy Japanese adults with (FBG) between 110–125 mg/dL.Methods: Subjects were randomly allocated into 2 groups (n = 33 per group) consumed 6 tablets/day either tablets bark extract containing (Acacia or placebo for 12 weeks. Evaluation points at screening, after 4-week (4w), 8-week (8w), 12-week intervention (12w). The primary outcome was FBG level w, whereas secondary outcomes 4w 8w, changes from Scr each-week intervention, percentage subjects below 110 mg/dL measured value change HbA1c, levels.Results: A total (18 men, 15 women) each group analyzed. had significantly lower 8 w than (P 0.030 P 0.014, respectively). <110 marginally higher 0.079). HbA1c lowered compared 0.015).Conclusions: confirmed have FBG-lowering effects.Trial registration: UMIN000039414Foundation: Acacia-No-Ki Co.,Ltd.Keywords: extract, Proanthocyanidins, Fasting level,